This study investigates whether electromyography (EMG) analysis can reflect ergonomic improvements for commuter bike users by assessing muscle activity differences between comfort- and performance-oriented saddle positions.A cohort of 30 city bike riders underwent a comprehensive fitting procedure, where one position was individually established ba
Developmentally Regulated Post-translational Modification of Nucleoplasmin Controls Histone Sequestration and Deposition
Nucleoplasmin (Npm) is an abundant histone chaperone in vertebrate oocytes Outdoor Rug and embryos.During embryogenesis, regulation of Npm histone binding is critical for its function in storing and releasing maternal histones to establish and maintain the zygotic epigenome.Here, we demonstrate that Xenopus laevis Npm post-translational modificatio
RetroMine, or how to provide in-depth retrospective studies from Medline in a glance: the hepcidin use-case
The rapid expansion of biomedical literature has provoked Fuse an increased development of advanced text mining tools to rapidly extract relevant events from the continuously increasing amount of knowledge published periodically in PubMed.However, bioinvestigators are still reluctant to use these tools for two reasons: i) a large volume of events i
Development of an in vivo RNAi protocol to investigate gene function in the filarial nematode, Brugia malayi.
Our ability to control diseases caused by parasitic nematodes is constrained by a limited portfolio of effective drugs and a paucity of robust tools to investigate parasitic nematode biology.RNA interference (RNAi) is a reverse-genetics tool with great potential to identify novel drug targets and interrogate parasite gene function, but present RNAi